A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma

Sonic Hedgehog (Shh) pathway regulates embryonic development of different organs including the thyroid gland. The aberrant activation of Shh signaling has been found in several types of cancer and according to recent evidences it represents an important regulator of tumor-stroma interaction. In this...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Parascandolo, Alessia, Laukkanen, Mikko O., De Rosa, Nancy, Ugolini, Clara, Cantisani, Maria Carmela, Cirafici, Anna Maria, Basolo, Fulvio, Santoro, Massimo, Castellone, Maria Domenica
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796990/
https://ncbi.nlm.nih.gov/pubmed/29435119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23388
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