A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma

Sonic Hedgehog (Shh) pathway regulates embryonic development of different organs including the thyroid gland. The aberrant activation of Shh signaling has been found in several types of cancer and according to recent evidences it represents an important regulator of tumor-stroma interaction. In this...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Parascandolo, Alessia, Laukkanen, Mikko O., De Rosa, Nancy, Ugolini, Clara, Cantisani, Maria Carmela, Cirafici, Anna Maria, Basolo, Fulvio, Santoro, Massimo, Castellone, Maria Domenica
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796990/
https://ncbi.nlm.nih.gov/pubmed/29435119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23388
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