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Conditional Estimation of Sensitivity and Specificity from a Phase 2 Biomarker Study Allowing Early Termination for Futility

Development of a disease screening biomarker involves several phases. In phase 2 its sensitivity and specificity is compared with established thresholds for minimally acceptable performance. Since we anticipate that most candidate markers will not prove to be useful and availability of specimens and...

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Библиографические подробности
Главные авторы: Pepe, Margaret Sullivan, Feng, Ziding, Longton, Gary, Koopmeiners, Joseph
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745932/
https://ncbi.nlm.nih.gov/pubmed/19097251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3506
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