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Conditional Estimation after a Two-stage Diagnostic Biomarker Study that Allows Early Termination for Futility

Many biomarkers identified in marker discovery are shown to have inadequate performance in validation studies. This motivates the use of group sequential designs that allow early termination for futility. However, an option for early termination will lead to biased estimates for studies that reach f...

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Библиографические подробности
Главные авторы: Koopmeiners, Joseph S., Feng, Ziding, Pepe, Margaret Sullivan
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641588/
https://ncbi.nlm.nih.gov/pubmed/22238117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4430
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