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Conditional Estimation after a Two-stage Diagnostic Biomarker Study that Allows Early Termination for Futility
Many biomarkers identified in marker discovery are shown to have inadequate performance in validation studies. This motivates the use of group sequential designs that allow early termination for futility. However, an option for early termination will lead to biased estimates for studies that reach f...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3641588/ https://ncbi.nlm.nih.gov/pubmed/22238117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4430 |
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