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Early Termination of a Two-Stage Study to Develop and Validate a Panel of Biomarkers
Two-stage designs to develop and validate a panel of biomarkers present a natural setting for the inclusion of stopping rules for futility in the event of poor preliminary estimates of performance. We consider the design of a two-stage study to develop and validate a panel of biomarkers where a pred...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3888241/ https://ncbi.nlm.nih.gov/pubmed/23413213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5622 |
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