The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function

TNFRSF13B, which encodes TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor), is mutated in 10% of patients with common variable immune deficiency (CVID). One of the 2 most common TACI mutations in CVID, A181E, introduces a negative charge into the transmembrane do...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, John J., Rauter, Ingrid, Garibyan, Lilit, Ozcan, Esra, Sannikova, Tatyana, Dillon, Stacey R., Cruz, Anthony C., Siegel, Richard M., Bram, Richard, Jabara, Haifa, Geha, Raif S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2009
Konular:
Immunobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745845/
https://ncbi.nlm.nih.gov/pubmed/19605846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-189720
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