Clinical Implications of KRAS Mutations in Lung Cancer Patients Treated with Tyrosine Kinase Inhibitors: An Important Role for Mutations in Minor Clones

Mutations inducing resistance to anti-epidermal growth factor receptor (EGFR) therapy may have a clinical impact even if present in minor cell clones which could expand during treatment. We tested this hypothesis in lung cancer patients treated with tyrosine kinase inhibitors (TKIs). Eighty-three pa...

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Bibliographic Details
Main Authors: Marchetti, Antonio, Milella, Michele, Felicioni, Lara, Cappuzzo, Federico, Irtelli, Luciana, Del Grammastro, Maela, Sciarrotta, Mariagrazia, Malatesta, Sara, Nuzzo, Carmen, Finocchiaro, Giovanna, Perrucci, Bruno, Carlone, Donatella, Gelibter, Alain J, Ceribelli, Anna, Mezzetti, Andrea, Iacobelli, Stefano, Cognetti, Francesco, Buttitta, Fiamma
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745674/
https://ncbi.nlm.nih.gov/pubmed/19794967
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