Mutational Profile of GNAQ (Q209) in Human Tumors

BACKGROUND: Frequent somatic mutations have recently been identified in the ras-like domain of the heterotrimeric G protein α-subunit (GNAQ) in blue naevi 83%, malignant blue naevi (50%) and ocular melanoma of the uvea (46%). The mutations exclusively affect codon 209 and result in GNAQ constitutive...

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Bibliographic Details
Main Authors: Lamba, Simona, Felicioni, Lara, Buttitta, Fiamma, Bleeker, Fonnet E., Malatesta, Sara, Corbo, Vincenzo, Scarpa, Aldo, Rodolfo, Monica, Knowles, Margaret, Frattini, Milo, Marchetti, Antonio, Bardelli, Alberto
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730032/
https://ncbi.nlm.nih.gov/pubmed/19718445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006833
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