Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQ(Q209P)-driven uveal melanomas in zebrafish

Mutations affecting Gαq proteins are pervasive in uveal melanoma (UM), suggesting they ‘drive’ UM pathogenesis. The ERK1/2-MAPK pathway is critical for cutaneous melanoma development and consequently an important therapeutic target. Defining the contribution of ERK1/2-MAPK signalling to UM developme...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Mouti, Mai Abdel, Dee, Christopher, Coupland, Sarah E., Hurlstone, Adam F.L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129960/
https://ncbi.nlm.nih.gov/pubmed/27166257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9207
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