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Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQ(Q209P)-driven uveal melanomas in zebrafish
Mutations affecting Gαq proteins are pervasive in uveal melanoma (UM), suggesting they ‘drive’ UM pathogenesis. The ERK1/2-MAPK pathway is critical for cutaneous melanoma development and consequently an important therapeutic target. Defining the contribution of ERK1/2-MAPK signalling to UM developme...
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| Udgivet i: | Oncotarget |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals LLC
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5129960/ https://ncbi.nlm.nih.gov/pubmed/27166257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9207 |
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