Complex Mutations & Subpopulations of Deletions at Exon 19 of EGFR in NSCLC Revealed by Next Generation Sequencing: Potential Clinical Implications

Microdeletions at exon 19 are the most frequent genetic alterations affecting the Epidermal Growth Factor Receptor (EGFR) gene in non-small cell lung cancer (NSCLC) and they are strongly associated with response to treatment with tyrosine kinase inhibitors. A series of 116 NSCLC DNA samples investig...

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Detaylı Bibliyografya
Asıl Yazarlar: Marchetti, Antonio, Del Grammastro, Maela, Filice, Giampaolo, Felicioni, Lara, Rossi, Giulio, Graziano, Paolo, Sartori, Giuliana, Leone, Alvaro, Malatesta, Sara, Iacono, Michele, Guetti, Luigi, Viola, Patrizia, Mucilli, Felice, Cuccurullo, Franco, Buttitta, Fiamma
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407088/
https://ncbi.nlm.nih.gov/pubmed/22848739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042164
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