Complex Mutations & Subpopulations of Deletions at Exon 19 of EGFR in NSCLC Revealed by Next Generation Sequencing: Potential Clinical Implications

Microdeletions at exon 19 are the most frequent genetic alterations affecting the Epidermal Growth Factor Receptor (EGFR) gene in non-small cell lung cancer (NSCLC) and they are strongly associated with response to treatment with tyrosine kinase inhibitors. A series of 116 NSCLC DNA samples investig...

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Bibliographic Details
Main Authors: Marchetti, Antonio, Del Grammastro, Maela, Filice, Giampaolo, Felicioni, Lara, Rossi, Giulio, Graziano, Paolo, Sartori, Giuliana, Leone, Alvaro, Malatesta, Sara, Iacono, Michele, Guetti, Luigi, Viola, Patrizia, Mucilli, Felice, Cuccurullo, Franco, Buttitta, Fiamma
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407088/
https://ncbi.nlm.nih.gov/pubmed/22848739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042164
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