Increase in Thiol Oxidative Stress via Glutathione Reductase Inhibition as a Novel Approach to Enhance Cancer Sensitivity to X-Ray Irradiation

Depletion of reduced form glutathione (GSH) has been extensively studied for its effect on sensitizing cancer to radiation. However, little is known about the effect of thiol oxidative stress created through an increase in glutathione disulfide (GSSG) on cancer sensitivity to radiation. In this stud...

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Bibliographic Details
Main Authors: Zhao, Yong, Seefeldt, Teresa, Chen, Wei, Carlson, Laura, Stoebner, Adam, Hanson, Sarah, Foll, Ryan, Matthees, Duane P., Palakurthi, Srinath, Guan, Xiangming
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745482/
https://ncbi.nlm.nih.gov/pubmed/19397999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.04.022
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