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Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
The binding of cAMP to the Escherichia coli catabolite gene activator protein (CAP) produces a conformational change that enables it to bind specific DNA sequences and regulate transcription, which it cannot do in the absence of the nucleotide. The crystal structures of the unliganded CAP containing...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745332/ https://ncbi.nlm.nih.gov/pubmed/19805344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908380106 |
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