Llwytho...

Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding

The binding of cAMP to the Escherichia coli catabolite gene activator protein (CAP) produces a conformational change that enables it to bind specific DNA sequences and regulate transcription, which it cannot do in the absence of the nucleotide. The crystal structures of the unliganded CAP containing...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sharma, Hitesh, Yu, Shaoning, Kong, Jilie, Wang, Jimin, Steitz, Thomas A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745332/
https://ncbi.nlm.nih.gov/pubmed/19805344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908380106
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