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Large, sequence-dependent effects on DNA conformation by minor groove binding compounds

To determine what topological changes antiparasitic heterocyclic dications can have on kinetoplast DNA, we have constructed ligation ladders, with phased A5 and ATATA sequences in the same flanking sequence context, as models. Bending by the A5 tract is observed, as expected, while the ATATA sequenc...

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Bibliografiske detaljer
Main Authors: Tevis, Denise S., Kumar, Arvind, Stephens, Chad E., Boykin, David W., Wilson, W. David
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760788/
https://ncbi.nlm.nih.gov/pubmed/19578063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp558
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