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Large, sequence-dependent effects on DNA conformation by minor groove binding compounds
To determine what topological changes antiparasitic heterocyclic dications can have on kinetoplast DNA, we have constructed ligation ladders, with phased A5 and ATATA sequences in the same flanking sequence context, as models. Bending by the A5 tract is observed, as expected, while the ATATA sequenc...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760788/ https://ncbi.nlm.nih.gov/pubmed/19578063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp558 |
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