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Large, sequence-dependent effects on DNA conformation by minor groove binding compounds
To determine what topological changes antiparasitic heterocyclic dications can have on kinetoplast DNA, we have constructed ligation ladders, with phased A5 and ATATA sequences in the same flanking sequence context, as models. Bending by the A5 tract is observed, as expected, while the ATATA sequenc...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760788/ https://ncbi.nlm.nih.gov/pubmed/19578063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp558 |
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