Naturally-acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism

Regulated upon activation, normal T-cell expressed, and secreted (RANTES, CCL-5) is an important immunoregulatory mediator that is suppressed in children with malarial anemia (MA). Although proinflammatory (e.g. TNF-α, IL-1β and IFN-γ) and anti-inflammatory (e.g., IL-4, IL-10 and IL-13) cytokines re...

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Main Authors: Were, Tom, Davenport, Gregory C., Yamo, Emmanuel O., Hittner, James B., Awandare, Gordon A., Otieno, Michael F., Ouma, Collins, Orago, Alloys S.S., Vulule, John M., Ong'echa, John M., Perkins, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745194/
https://ncbi.nlm.nih.gov/pubmed/19427395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.micinf.2009.04.021
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