Acquisition of Hemozoin by Monocytes Down-Regulates Interleukin-12 p40 (IL-12p40) Transcripts and Circulating IL-12p70 through an IL-10-Dependent Mechanism: In Vivo and In Vitro Findings in Severe Malarial Anemia

Severe malarial anemia (SMA) is a primary cause of morbidity and mortality in immune-naïve infants and young children residing in areas of holoendemic Plasmodium falciparum transmission. Although the immunopathogenesis of SMA is largely undefined, we have previously shown that systemic interleukin-1...

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Bibliographic Details
Main Authors: Keller, Christopher C., Yamo, Ouma, Ouma, Collins, Ong'echa, John Michael, Ounah, David, Hittner, James B., Vulule, John M., Perkins, Douglas J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Fungal and Parasitic Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1594872/
https://ncbi.nlm.nih.gov/pubmed/16926419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00843-06
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