Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence

Salvinorin A (SA) is a potent kappa opioid with a brief duration of action. Consistent with this, our previous positron emission tomography (PET) studies of carbon-11 labeled SA showed that brain levels decrease rapidly after intravenous administration. SA is rapidly metabolized, giving the much les...

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Autori principali: Hooker, Jacob M., Munro, Thomas A., Béguin, Cécile, Alexoff, David, Shea, Colleen, Xu, Youwen, Cohen, Bruce M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745083/
https://ncbi.nlm.nih.gov/pubmed/19591852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2009.06.044
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