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Inhibitors of Src Homology-2 Domain containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds
Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-117199) which inhibits the protein tyrosine phosphatase (PTP) Shp2 with an IC(50) of 47 μM. A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activi...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744494/ https://ncbi.nlm.nih.gov/pubmed/18680359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8002526 |
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