Inhibitors of Src Homology-2 Domain containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-117199) which inhibits the protein tyrosine phosphatase (PTP) Shp2 with an IC(50) of 47 μM. A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activi...

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Detalhes bibliográficos
Main Authors: Lawrence, Harshani R., Pireddu, Roberta, Chen, Liwei, Luo, Yunting, Sung, Shen-Shu, Szymanski, Ann Marie, Richard Yip, M. L., Guida, Wayne C., Sebti, Saïd M., Wu, Jie, Lawrence, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744494/
https://ncbi.nlm.nih.gov/pubmed/18680359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8002526
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