Protective Effect of Delayed Treatment With Low-Dose Glibenclamide in Three Models of Ischemic Stroke

BACKGROUND AND PURPOSE: Ischemia/hypoxia induces de novo expression of the sulfonylurea receptor 1-regulated NC(Ca-ATP) channel. In rodent models of ischemic stroke, early postevent administration of the sulfonylurea, glibenclamide, is highly effective in reducing edema, mortality, and lesion volume...

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Hauptverfasser: Simard, J. Marc, Yurovsky, Vladimir, Tsymbalyuk, Natalia, Melnichenko, Ludmila, Ivanova, Svetlana, Gerzanich, Volodymyr
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744391/
https://ncbi.nlm.nih.gov/pubmed/19023097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.108.522409
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