Constitutive Activity at the Cannabinoid CB(1) Receptor Is Required for Behavioral Response to Noxious Chemical Stimulation of TRPV1: Antinociceptive Actions of CB1 Inverse Agonists

The potential modulation of TRPV1 nociceptive activity by the CB(1) receptor was investigated here using CB(1) wild-type (WT) and knock-out (KO) mice as well as selective CB(1) inverse agonists. No significant differences were detected in baseline thermal thresholds of ICR, CB(1)WT or CB(1)KO mice....

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Main Authors: Fioravanti, Beatriz, De Felice, Milena, Stucky, Cheryl L., Medler, Karen A., Luo, Miaw-Chyi, Gardell, Luis R., Ibrahim, Mohab, Malan, T. Phil, Yamamura, Henry I., Ossipov, Michael H., King, Tamara, Lai, Josephine, Porreca, Frank, Vanderah, Todd W.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744288/
https://ncbi.nlm.nih.gov/pubmed/18987195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3322-08.2008
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