The Polycomb Group Gene Bmi1 Regulates Antioxidant Defenses in Neurons by Repressing p53 Pro-Oxidant Activity

Aging may be determined by a genetic program and/or by the accumulation rate of molecular damages. Reactive oxygen species (ROS) generated by the mitochondrial metabolism have been postulated to be the central source of molecular damages and imbalance between levels of intracellular ROS and antioxid...

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Bibliographic Details
Main Authors: Chatoo, Wassim, Abdouh, Mohamed, David, Jocelyn, Champagne, Marie-Pier, Ferreira, José, Rodier, Francis, Bernier, Gilbert
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744209/
https://ncbi.nlm.nih.gov/pubmed/19144853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5303-08.2009
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