Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1+/− mice

Sporadic Alzheimer’s disease (AD) is the most common cause of dementia. However, representative experimental models of AD have remained difficult to produce because of the disease’s uncertain origin. The Polycomb group protein BMI1 regulates chromatin compaction and gene silencing. BMI1 expression i...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: El Hajjar, Jida, Chatoo, Wassim, Hanna, Roy, Nkanza, Patrick, Tétreault, Nicolas, Tse, Yiu Chung, Wong, Tak Pan, Abdouh, Mohamed, Bernier, Gilbert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346086/
https://ncbi.nlm.nih.gov/pubmed/30679733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37444-3
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