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A Mechanism Linking Extra Centrosomes to Chromosomal Instability

Chromosome instability (CIN) is a hallmark of many tumors and correlates with the presence of extra centrosomes1-4. However, a direct mechanistic link between extra centrosomes and CIN has not been established. It has been proposed that extra centrosomes generate CIN by promoting multipolar anaphase...

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Bibliographic Details
Main Authors: Ganem, Neil J., Godinho, Susana A., Pellman, David
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743290/
https://ncbi.nlm.nih.gov/pubmed/19506557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08136
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