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A General and Efficient Method for the Site-Specific Dual-Labeling of Proteins for Single Molecule FRET

[Image: see text] A general strategy for the site-specific dual-labeling of proteins for single-molecule fluorescence resonance energy transfer (smFRET) is presented. A genetically encoded unnatural ketone amino acid was labeled with a hydroxylamine-containing fluorophore with high yield (>95%) a...

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Autors principals: Brustad, Eric M., Lemke, Edward A., Schultz, Peter G., Deniz, Ashok A.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743202/
https://ncbi.nlm.nih.gov/pubmed/19108697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807430h
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