Site-specific dual-color labeling of long RNAs for single-molecule spectroscopy

Labeling of long RNA molecules in a site-specific yet generally applicable manner is integral to many spectroscopic applications. Here we present a novel covalent labeling approach that is site-specific and scalable to long intricately folded RNAs. In this approach, a custom-designed DNA strand that...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Zhao, Meng, Steffen, Fabio D, Börner, Richard, Schaffer, Michelle F, Sigel, Roland K O, Freisinger, Eva
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814972/
https://ncbi.nlm.nih.gov/pubmed/29136199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1100
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