Functional Islet-Specific Regulatory T Cells Can Be Generated from CD4(+)CD25(−) T cells of Healthy and Type 1 Diabetic Subjects

CD4(+)CD25(+)FOXP3(+) Treg cells require TCR engagement for suppressive function, thus ensuring that suppression only occurs in the presence of specific antigens, however, to date no studies have addressed the function of self antigen-specific Treg in humans. These studies were designed to determine...

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Main Authors: Long, S. Alice, Walker, Mindi R., Rieck, Mary, James, Eddie, Kwok, William W., Sanda, Srinath, Pihoker, Catherine, Greenbaum, Carla, Nepom, Gerald T, Buckner, Jane H
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743096/
https://ncbi.nlm.nih.gov/pubmed/19180473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838819
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