Functional Islet-Specific Regulatory T Cells Can Be Generated from CD4(+)CD25(−) T cells of Healthy and Type 1 Diabetic Subjects

CD4(+)CD25(+)FOXP3(+) Treg cells require TCR engagement for suppressive function, thus ensuring that suppression only occurs in the presence of specific antigens, however, to date no studies have addressed the function of self antigen-specific Treg in humans. These studies were designed to determine...

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Huvudupphovsmän: Long, S. Alice, Walker, Mindi R., Rieck, Mary, James, Eddie, Kwok, William W., Sanda, Srinath, Pihoker, Catherine, Greenbaum, Carla, Nepom, Gerald T, Buckner, Jane H
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743096/
https://ncbi.nlm.nih.gov/pubmed/19180473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838819
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