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Activation of decapping involves binding of the mRNA and facilitation of the post-binding steps by the Lsm1-7–Pat1 complex

Decapping is a critical step in the conserved 5′-to-3′ mRNA decay pathway of eukaryotes. The hetero-octameric Lsm1-7–Pat1 complex is required for normal rates of decapping in this pathway. This complex also protects the mRNA 3′-ends from trimming in vivo. To elucidate the mechanism of decapping, we...

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Bibliographic Details
Main Authors: Chowdhury, Ashis, Tharun, Sundaresan
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743039/
https://ncbi.nlm.nih.gov/pubmed/19643916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1650109
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