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The decapping activator Lsm1p-7p–Pat1p complex has the intrinsic ability to distinguish between oligoadenylated and polyadenylated RNAs
Decapping is a critical step in mRNA decay. In the 5′-to-3′ mRNA decay pathway conserved in all eukaryotes, decay is initiated by poly(A) shortening, and oligoadenylated mRNAs (but not polyadenylated mRNAs) are selectively decapped allowing their subsequent degradation by 5′ to 3′ exonucleolysis. Th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1894922/ https://ncbi.nlm.nih.gov/pubmed/17513695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.502507 |
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