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lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex to preferentially bind to oligoadenylated RNA affect mRNA decay in vivo

The poly(A) tail is a crucial determinant in the control of both mRNA translation and decay. Poly(A) tail length dictates the triggering of the degradation of the message body in the major 5′ to 3′ and 3′ to 5′ mRNA decay pathways of eukaryotes. In the 5′ to 3′ pathway oligoadenylated but not polyad...

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Bibliografski detalji
Glavni autori: Chowdhury, Ashis, Tharun, Sundaresan
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553750/
https://ncbi.nlm.nih.gov/pubmed/18719247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1094208
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