Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal Cells In Vitro and Increases Reticulocyte Micronuclei after Total-Body Irradiation

Mammalian POLQ (pol θ) is a specialized DNA polymerase with an unknown function in vivo. Roles have been proposed in chromosome stability, as a backup enzyme in DNA base excision repair, and in somatic hypermutation of immunoglobulin genes. The purified enzyme can bypass AP sites and thymine glycol....

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Detalhes bibliográficos
Main Authors: Goff, Julie P., Shields, Donna S., Seki, Mineaki, Choi, Serah, Epperly, Michael W., Dixon, Tracy, Wang, Hong, Bakkenist, Christopher J., Dertinger, Stephen D., Torous, Dorothea K., Wittschieben, John, Wood, Richard D., Greenberger, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742993/
https://ncbi.nlm.nih.gov/pubmed/19630521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1598.1
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