Crystal Structure of the N-Acetylmannosamine Kinase Domain of GNE

BACKGROUND: UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, GNE, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy. GNE is the only human protein that contains a kinase domai...

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Main Authors: Tong, Yufeng, Tempel, Wolfram, Nedyalkova, Lyudmila, MacKenzie, Farrell, Park, Hee-Won
格式: Artigo
語言:Inglês
出版: Public Library of Science 2009
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742894/
https://ncbi.nlm.nih.gov/pubmed/19841673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007165
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