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Cab45b, a Munc18b-interacting Partner, Regulates Exocytosis in Pancreatic β-Cells

Cab45b is a cytosolic Ca(2+)-binding protein reported to regulate zymogen secretion in pancreatic acini. We now show that Cab45b is also expressed in pancreatic islet β-cells and interacts there with the Sec1-Munc18 protein Munc18b. We employed patch clamp cell capacitance measurements to show that...

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Detalhes bibliográficos
Main Authors: Zhang, Yi, Kang, You-hou, Chang, Nathan, Lam, Patrick P. L., Liu, Yunfeng, Olkkonen, Vesa M., Gaisano, Herbert Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742849/
https://ncbi.nlm.nih.gov/pubmed/19487699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017467
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