The N-peptide–binding mode is critical to Munc18-1 function in synaptic exocytosis

Sec1/Munc18 (SM) proteins promote intracellular vesicle fusion by binding to N-ethylmaleimide–sensitive factor attachment protein receptors (SNAREs). A key SNARE-binding mode of SM proteins involves the N-terminal peptide (N-peptide) motif of syntaxin, a SNARE subunit localized to the target membran...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Shen, Chong, Liu, Yinghui, Yu, Haijia, Gulbranson, Daniel R., Kogut, Igor, Bilousova, Ganna, Zhang, Chen, Stowell, Michael H. B., Shen, Jingshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Membrane Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254354/
https://ncbi.nlm.nih.gov/pubmed/30275014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005254
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