Point Mutations in Membrane Proteins Reshape Energy Landscape and Populate Different Unfolding Pathways

Using single-molecule force spectroscopy, we investigated the effect of single point mutations on the energy landscape and unfolding pathways of the transmembrane protein bacteriorhodopsin. We show that the unfolding energy barriers in the energy landscape of the membrane protein followed a simple t...

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Main Authors: Sapra, K. Tanuj, Balasubramanian, G. Prakash, Labudde, Dirk, Bowie, James U., Muller, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742699/
https://ncbi.nlm.nih.gov/pubmed/18191146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.12.027
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