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Rerouting the folding pathway of the Notch ankyrin domain by reshaping the energy landscape

The modular nature of repeat proteins has made them a successful target for protein design. Ankyrin repeat, TPR, and leucine rich repeat domains that have been designed solely on consensus information have been shown to have higher thermostability than their biological counterparts. We have previous...

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Detalles Bibliográficos
Main Authors: Tripp, Katherine W., Barrick, Doug
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474552/
https://ncbi.nlm.nih.gov/pubmed/18396879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0763201
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