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Rerouting the folding pathway of the Notch ankyrin domain by reshaping the energy landscape
The modular nature of repeat proteins has made them a successful target for protein design. Ankyrin repeat, TPR, and leucine rich repeat domains that have been designed solely on consensus information have been shown to have higher thermostability than their biological counterparts. We have previous...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474552/ https://ncbi.nlm.nih.gov/pubmed/18396879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0763201 |
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