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X11α haploinsufficiency enhances Aβ amyloid deposition in Alzheimer’s disease transgenic mice
The neuronal adaptor protein X11α/mint-1/APBA-1 binds to the cytoplasmic domain of the amyloid precursor protein (APP) to modulate its trafficking and metabolism. We investigated the consequences of reducing X11α in a mouse model of Alzheimer’s disease (AD). We crossed hAPPswe/PS-1ΔE9 transgenic (AD...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742573/ https://ncbi.nlm.nih.gov/pubmed/19631749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.07.006 |
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