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DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations

DNA polymerase γ is the only known DNA polymerase in human mitochondria and is essential for mitochondrial DNA replication and repair. It is well established that defects in mtDNA replication lead to mitochondrial dysfunction and disease. Over 160 coding variations in the gene encoding the catalytic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chan, Sherine S. L., Copeland, William C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742478/
https://ncbi.nlm.nih.gov/pubmed/19010300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2008.10.007
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