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DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations

DNA polymerase γ is the only known DNA polymerase in human mitochondria and is essential for mitochondrial DNA replication and repair. It is well established that defects in mtDNA replication lead to mitochondrial dysfunction and disease. Over 160 coding variations in the gene encoding the catalytic...

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Main Authors: Chan, Sherine S. L., Copeland, William C.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742478/
https://ncbi.nlm.nih.gov/pubmed/19010300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2008.10.007
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