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DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations
DNA polymerase γ is the only known DNA polymerase in human mitochondria and is essential for mitochondrial DNA replication and repair. It is well established that defects in mtDNA replication lead to mitochondrial dysfunction and disease. Over 160 coding variations in the gene encoding the catalytic...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742478/ https://ncbi.nlm.nih.gov/pubmed/19010300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2008.10.007 |
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