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DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations

DNA polymerase γ is the only known DNA polymerase in human mitochondria and is essential for mitochondrial DNA replication and repair. It is well established that defects in mtDNA replication lead to mitochondrial dysfunction and disease. Over 160 coding variations in the gene encoding the catalytic...

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Bibliografiske detaljer
Main Authors: Chan, Sherine S. L., Copeland, William C.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742478/
https://ncbi.nlm.nih.gov/pubmed/19010300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2008.10.007
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