The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development

The nonreceptor tyrosine phosphatase Shp2 (PTPN11) has been implicated in tyrosine kinase, cytokine, and integrin receptor signaling. We show here that conditional mutation of Shp2 in neural crest cells and in myelinating Schwann cells resulted in deficits in glial development that are remarkably si...

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Détails bibliographiques
Auteurs principaux: Grossmann, Katja S., Wende, Hagen, Paul, Florian E., Cheret, Cyril, Garratt, Alistair N., Zurborg, Sandra, Feinberg, Konstantin, Besser, Daniel, Schulz, Herbert, Peles, Elior, Selbach, Matthias, Birchmeier, Walter, Birchmeier, Carmen
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742405/
https://ncbi.nlm.nih.gov/pubmed/19805360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904336106
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