Peripheral sensitisation of nociceptors via G-proteindependent potentiation of mechanotransduction currents

Mechanical stimuli impinging on the skin are converted into electrical signals by mechanically gated ion channels located at the peripheral nerve endings of dorsal root ganglion (DRG) neurons. Under inflammatory conditions sensory neurons are commonly sensitised to mechanical stimuli; a putative mec...

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Bibliographic Details
Main Authors: Lechner, Stefan G, Lewin, Gary R
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2009
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742277/
https://ncbi.nlm.nih.gov/pubmed/19505980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.175059
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