An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors

Understanding information flow in sensory pathways requires cell-selective approaches to manipulate the activity of defined neurones. Primary afferent nociceptors, which detect painful stimuli, are enriched in specific voltage-gated sodium channel (VGSC) subtypes. Toxins derived from venomous animal...

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Bibliographic Details
Main Authors: Stürzebecher, Annika S, Hu, Jing, Smith, Ewan St John, Frahm, Silke, Santos-Torres, Julio, Kampfrath, Branka, Auer, Sebastian, Lewin, Gary R, Ibañez-Tallon, Inés
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2010
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887988/
https://ncbi.nlm.nih.gov/pubmed/20308253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.187112
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