Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

Although endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain are uncertain. Clinical exploitation of the system is severely hindered by the cognitive deficits, memory impairme...

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Autori principali: Agarwal, Nitin, Pacher, Pal, Tegeder, Irmgard, Amaya, Fumimasa, Constantin, Cristina E, Brenner, Gary J, Rubino, Tiziana, Michalski, Christoph W, Marsicano, Giovanni, Monory, Krisztina, Mackie, Ken, Marian, Claudiu, Batkai, Sandor, Parolaro, Daniela, Fischer, Michael J, Reeh, Peter, Kunos, George, Kress, Michaela, Lutz, Beat, Woolf, Clifford J, Kuner, Rohini
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234438/
https://ncbi.nlm.nih.gov/pubmed/17558404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1916
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