A Molecular Basis of Analgesic Tolerance to Cannabinoids

Clinical usage of cannabinoids in chronic pain states is limited by their central side effects and the pharmacodynamic tolerance that sets in after repeated dosage. Analgesic tolerance to cannabinoids in vivo could be caused by agonist-induced downregulation and intracellular trafficking of cannabin...

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Vydáno v:J Neurosci
Hlavní autoři: Tappe-Theodor, Anke, Agarwal, Nitin, Katona, István, Rubino, Tiziana, Martini, Lene, Swiercz, Jakub, Mackie, Ken, Monyer, Hannah, Parolaro, Daniela, Whistler, Jennifer, Kuner, Thomas, Kuner, Rohini
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672554/
https://ncbi.nlm.nih.gov/pubmed/17428994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5648-06.2007
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