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STIM1 and calmodulin interact with Orai1 to induce Ca(2+)-dependent inactivation of CRAC channels

Ca(2+)-dependent inactivation (CDI) is a key regulator and hallmark of the Ca(2+) release-activated Ca(2+) (CRAC) channel, a prototypic store-operated Ca(2+) channel. Although the roles of the endoplasmic reticulum Ca(2+) sensor STIM1 and the channel subunit Orai1 in CRAC channel activation are beco...

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Autori principali: Mullins, Franklin M., Chan, Young Park, Dolmetsch, Ricardo E., Lewis, Richard S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741279/
https://ncbi.nlm.nih.gov/pubmed/19706428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906781106
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