STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

Store-operated Ca(2+) channels activated by the depletion of Ca(2+) from the endoplasmic reticulum (ER) are a major Ca(2+) entry pathway in non-excitable cells and are essential for T cell activation and adaptive immunity. Following store depletion, the ER Ca(2+) sensor STIM1 and the CRAC channel pr...

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Main Authors: Park, Chan Young, Hoover, Paul J., Mullins, Franklin M., Bachhawat, Priti, Covington, Elizabeth D., Raunser, Stefan, Walz, Thomas, Garcia, K. Christopher, Dolmetsch, Ricardo E., Lewis, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670439/
https://ncbi.nlm.nih.gov/pubmed/19249086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.02.014
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