The antiproliferative cytostatic effects of a self-activating viridin prodrug

Although viridins like wortmannin (Wm) have long been examined as anticancer agents, their ability to self-activate has only recently been recognized. Here, we describe the cytostatic effects of a self-activating viridin (SAV), which is an inactive, polymeric prodrug. SAV self-activates to generate...

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Autori principali: Smith, Adam, Blois, Joseph, Yuan, Hushan, Aikawa, Elena, Ellson, Christian, Figueiredo, Jose-Luiz, Weissleder, Ralph, Kohler, Rainer, Yaffe, Michael B., Cantley, Lewis C., Josephson, Lee
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740925/
https://ncbi.nlm.nih.gov/pubmed/19509266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1012
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