Abrogation of Antibody-Induced Arthritis in Mice by a Self-Activating Viridin Prodrug and Association With Impaired Neutrophil and Endothelial Cell Function

OBJECTIVE: To test a novel self-activating viridin (SAV) prodrug that slowly releases wortmannin, a potent phosphoinositide 3-kinase inhibitor, in a model of antibody-mediated inflammatory arthritis. METHODS: The SAV prodrug was administered to K/BxN mice or to C57BL/6 (B6) mice that had been inject...

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Main Authors: Stangenberg, Lars, Ellson, Chris, Cortez-Retamozo, Virna, Ortiz-Lopez, Adriana, Yuan, Hushan, Blois, Joseph, Smith, Ralph A., Yaffe, Michael B., Weissleder, Ralph, Benoist, Christophe, Mathis, Diane, Josephson, Lee, Mahmood, Umar
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080016/
https://ncbi.nlm.nih.gov/pubmed/19644878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24704
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