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Abrogation of Antibody-Induced Arthritis in Mice by a Self-Activating Viridin Prodrug and Association With Impaired Neutrophil and Endothelial Cell Function
OBJECTIVE: To test a novel self-activating viridin (SAV) prodrug that slowly releases wortmannin, a potent phosphoinositide 3-kinase inhibitor, in a model of antibody-mediated inflammatory arthritis. METHODS: The SAV prodrug was administered to K/BxN mice or to C57BL/6 (B6) mice that had been inject...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3080016/ https://ncbi.nlm.nih.gov/pubmed/19644878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24704 |
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