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Slow Self-Activation Enhances The Potency of Virdin Prodrugs
When the virdin wortmannin (Wm) is modified at the C20 position, it exhibits a superior antiproliferative activity even though a covalent reaction between the C20 of Wm and a lysine in the active site of PI3 kinase is essential to Wm’s mechanism of action. The improved potency results from a self-ac...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2663427/ https://ncbi.nlm.nih.gov/pubmed/18630894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800374f |
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