Rpb9 Subunit Controls Transcription Fidelity by Delaying NTP Sequestration in RNA Polymerase II

Rpb9 is a small non-essential subunit of yeast RNA polymerase II located on the surface on the enzyme. Deletion of the RPB9 gene shows synthetic lethality with the low fidelity rpb1-E1103G mutation localized in the trigger loop, a mobile element of the catalytic Rpb1 subunit, which has been shown to...

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Main Authors: Walmacq, Celine, Kireeva, Maria L., Irvin, Jordan, Nedialkov, Yuri, Lubkowska, Lucyna, Malagon, Francisco, Strathern, Jeffrey N., Kashlev, Mikhail
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740586/
https://ncbi.nlm.nih.gov/pubmed/19439405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006908
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